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Caring for your dog’s cellular health and aging wellness is like learning to play a musical instrument. Consistent, focused practice sessions allow you to build proficiency over time, turning initial effort into long-term mastery and accomplishment. Consistent administration of Leap Years every day, results in improvements in cellular health and overall metabolic health over time.
If you have seen changes in your dog’s attentiveness and engagement, after you started Leap Years, great! But don’t stop there—by sticking to your daily administration of Leap Years, you can keep your dog on track for years of healthy aging. Even without seeing physical changes, rest assured that your dog’s cellular health is being supported.
The primary reason to strive to remember to give Leap Years every day is related to your dog’s circadian rhythm. The circadian rhythm is a 24-hour clock in the brain which regulates cycles of alertness and sleepiness by responding to light in the environment. Circadian comes from the Latin, “circa” which means around and “dies” which means day. The circadian rhythm is vital to regulating cellular, physiologic and behavioral systems in the body. (Katsyuba, 2020)
NAD plays an essential role in the circadian rhythm of the brain. Because NAD is an essential cofactor for the biochemistry and metabolism of cells, changes in NAD metabolism is associated with aging and multiple diseases. (Katsyuba, 2017)
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Reasons to make administration of Leap Years a daily habit:
- Consistent Levels: NAD+ is a crucial coenzyme involved in various cellular metabolism production and various metabolic processes. Daily supplementation helps maintain stable NAD+ levels in the body, which can support continuous cellular health.
- Sustained Benefits: Many of the benefits associated with NAD+ supplementation, such as improved cellular function, may be more pronounced with regular use. Consistent administration ensures a steady supply of NAD+ to support these processes.
- Optimized Metabolism: NAD+ plays a supportive role in regulating metabolism and repairing DNA. Daily administration can help sustain these essential functions in your dog for better overall metabolic health.
- Long-Term Effects: For support of healthy aging, daily intake may provide more reliable and measurable results over time compared to intermittent use.
- Preventing Fluctuations: Regular supplementation helps prevent potential fluctuations in NAD+ levels, which can impact cellular function and overall wellness.
Summary
In summary, daily administration of Leap Years maintains consistent levels of NAD+ in your dog’s body and supports long-term health. So remember to give Leap Years daily to meet the needs of every cell in your dog’s body.
Katsyuba E, Romani M, Hofer D, Auwerx J. NAD+ homeostasis in health and disease. Nat Metab. 2020 Jan;2(1):9-31. doi: 10.1038/s42255-019-0161-5. Epub 2020 Jan 20. PMID: 32694684.
Cuenoud B, Huang Z, Hartweg M, Widmaier M, Lim S, Wenz D, Xin L. Effect of circadian rhythm on NAD and other metabolites in human brain. Front Physiol. 2023 Nov 9;14:1285776. doi: 10.3389/fphys.2023.1285776. PMID: 38028810; PMCID: PMC10665902.
Katsyuba E, Auwerx J. Modulating NAD+ metabolism, from bench to bedside. EMBO J. 2017 Sep 15;36(18):2670-2683. doi: 10.15252/embj.201797135. Epub 2017 Aug 7. PMID: 28784597; PMCID: PMC5599801.
