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The science behind Leap Years
Most dog supplements borrow their science from mice or people. Leap Years was put through a randomized, placebo-controlled trial at the NC State College of Veterinary Medicine, and the results were published in a peer-reviewed journal. Here is that science, in plain words.
Read the published study
Science-backed Formula
Veterinarian Developed
CLINICALLY STUDIED IN DOGS
MADE IN USA
Science-backed Formula
Veterinarian Developed
CLINICALLY STUDIED IN DOGS
MADE IN USA
Science-backed Formula
Veterinarian Developed
CLINICALLY STUDIED IN DOGS
MADE IN USA
Science-backed Formula
Veterinarian Developed
CLINICALLY STUDIED IN DOGS
MADE IN USA
Science-backed Formula
Veterinarian Developed
CLINICALLY STUDIED IN DOGS
MADE IN USA
If you only have a minute, this is the whole page.
An NAD+ precursor that helps cells keep their energy supply. And a senolytic, given two days a month, that supports the body's natural clearing of worn-out cells.
In the trial, senior dogs on the full dose showed the largest improvement in cognitive function, as rated by their owners. A statistically significant result, published in a peer-reviewed journal.
Well tolerated in the trial, with safety checks on par with placebo. A soft, beef-flavored chew most dogs take like a treat, once every morning.
Scientists have mapped the key processes behind aging, called the hallmarks of aging. Leap Years is built around two of them.
NAD+ is a molecule every cell uses to turn food into energy and to keep itself in good repair. Research shows NAD+ levels fall as the body ages. Supporting NAD+ helps cells keep doing their job.
Some cells stop working but do not clear out. Researchers call them senescent, or "zombie," cells, and they send out signals that disturb the healthy cells around them. Supporting the body's natural clearing of these cells helps the healthy ones thrive.
Clear out what is not working. Refuel what is. Most supplements pick one lever. Leap Years works on both, and it is this exact combination that was tested in the NC State trial.
Leap Years is a monthly cycle, not a single pill. The schedule below is the same one used in the NC State trial.
LY-D6 · Senolytic + NAD+ precursor
Two days in a row at the start of each month. It supports the body's natural clearing of senescent cells and gives NAD+ a boost.
LY-D2 · NAD+ precursor
Once every morning for the rest of the month. It keeps supporting NAD+ day to day. Then the cycle starts again.
Same schedule as the study. In the trial, dogs got the NAD+ precursor daily and the senolytic on two days in a row each month. Doses were set from earlier safety and dosing studies, and the serving scales with your dog's weight.
Most dog supplements are never tested in dogs. This one was tested the way medicines are: against a placebo, with nobody knowing who got what.
A computer decided which dog went in which group. That keeps the groups fair.
One group got look-alike chews with nothing active. It is the fair comparison every result is measured against.
Neither owners nor researchers knew which dog got what until the analysis was done.
Independent scientists reviewed the work before the journal published it.
Main result · 3 months
Senior dogs on Leap Years showed improved cognitive function, as assessed by their owners. The full dose delivered the largest improvement.
"We conclude that LY-D6/2 improves owner-assessed cognitive function over a 3-month period and may have broader, but more subtle effects on frailty, activity and happiness as reported by owners."The study authors, Scientific Reports, 2024
p = 0.02 on the main measure
A p-value of 0.02 means a result this strong would show up by chance only about 2 times in 100. That clears the bar scientists use to call a result statistically significant.
The CCDR, a 13-question rating scale used by veterinary researchers to track cognitive function in senior dogs. It covers everyday behavior, like recognizing familiar people and finding the way around the house.
Owners see their dog every day, at home, in real life. Not for twenty minutes in an exam room.
That is why veterinary researchers rely on validated owner scales like the CCDR to measure cognitive function in senior dogs. It captures the dog you actually live with.
The questions owners answered are about everyday life: does the dog recognize familiar people, find its way around the house, and move through its day without getting stuck or lost.
That is what improved most in the full-dose group. Not a lab score. The dog you live with.
In the NC State trial, dogs on Leap Years did as well on safety checks and bloodwork as dogs on placebo. The researchers described the chews as well tolerated.
A soft, beef-flavored chew that most dogs take like a treat.
Active ingredients and soft chews are made in FDA-registered, audited facilities, under the same Current Good Manufacturing Practice (cGMP) standard set by the FDA for pharmaceutical products.
Every batch is tested and inspected before release to confirm it meets specification and is free of contaminants. An adverse event reporting system flags any safety or quality concern immediately.
The study measured its main result at 90 days. Here is what the first three months look like.
Month 1Golden chews on days 1 and 2, then one brown chew every morning. It takes seconds, and most dogs take it like a treat. Jot down a few notes on how your dog is today.
Month 2A new golden chew reset starts the month. Keep the routine going every morning. Consistency is what the study measured.
Month 3This is when the NC State trial measured its main result. Look back at your month 1 notes and see what has changed.
These are the everyday signs the study tracked.
Chief Veterinary Medical Officer,
Animal Biosciences.
A review of 12 connected processes behind aging, including cellular senescence and changes in how cells use energy.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Cell, 2023.
Read the paperA review of NAD+ in metabolism and cell health, how NAD+ levels change with age, and what boosting it has done in animal studies.
Rajman L, Chwalek K, Sinclair DA. Cell Metabolism, 2018.
Read the paperA review of senescent cells, the signals they send out, and how energy problems inside cells relate to them.
Wiley CD, Campisi J. Nature Metabolism, 2021.
Read the paperA study of how long pet dogs live. Large dogs live shorter lives on average than small dogs, independent of breed ancestry.
Urfer SR, Kaeberlein M, Promislow DEL, Creevy KE. Canine Medicine and Genetics, 2020.
Read the paperSimon KE, Russell K, Mondino A, Yang CC, Case BC, Anderson Z, Whitley C, Griffith E, Gruen ME, Olby NJ. A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination. Scientific Reports. 2024;14:12399. DOI: 10.1038/s41598-024-63031-w
The full paper, including all secondary measures, is open access. We are happy to send it to your clinic.
Request vet informationA two-part daily chew, clinically studied in dogs and published in a peer-reviewed journal. Start your dog's first 90 days today.
