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Understanding potential interactions for dog supplements is crucial to minimize risks and optimize outcomes for aging dogs. Interactions can occur between prescription medications, over-the-counter drugs, supplements, or even food. They may result in increased or decreased drug concentrations in the body, affecting how the medications work and potentially leading to adverse reactions or reduced efficacy. Anytime we add a new medication or supplement to our dog’s healthy aging regimen, it is important to watch for any changes and promptly discuss them with your veterinarian.
Leap Years and Other Supplements
There are no known contraindications for the use of Leap Years with other medications and supplements. The NAD booster in Leap Years is a Vitamin B3 derivative, so we don’t want to double up on the B vitamins. Some senior dog foods, mutivitamins and treats such as Greenies Dental Treats, contain varying amounts of Vitamin B3 as part of their formulation. So check the labels of any product administered if they are used in conjunction with Leap Years.
NAD Boosting
Let’s dive a little deeper into why Leap Years contains two components, an NAD booster and a senolytic. NAD is an important cofactor for many cellular processes of the mitochondria, the powerhouse of cells. NAD is important in aging, not only because its concentration wanes with age, but it is involved in the activation of sirtuins, a class of proteins important in DNA repair, metabolism and longevity. In mammals including dogs, there are seven known sirtuin proteins, labeled as SIRT1 through SIRT7. SIRT1 is perhaps the most extensively studied and is known for its role in regulating aging and longevity-related pathways. It has been linked to protection against age-related diseases such as cancer, neurodegeneration, and cardiovascular diseases.
Senolytics
The senolytic in Leap Years is a polyphenol compound shown to aid in the natural clearance of senescent cells. Senescent cells are cells that have entered a state of irreversible growth arrest, typically in response to stress or damage, and they accumulate with age. While senescence is a natural process that serves to prevent damaged cells from becoming cancerous, the accumulation of senescent cells over time is associated with dog aging and age-related diseases. Senescent cells secrete a variety of factors which can promote canine inflammation and tissue dysfunction, contributing to age-related pathologies such as chronic inflammation.
Polyphenols are a diverse group of naturally occurring compounds found in plants, including fruits, vegetables, nuts, seeds, tea, coffee, and red wine. Research into polyphenols continues to uncover their potential health-promoting properties and their role in preventing chronic diseases and promoting overall well-being. The specific effects of individual polyphenols can vary based on factors such as their bioavailability, metabolism, and interactions with other nutrients.
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Bioavailability
Overall, while dogs and humans share many physiological similarities, there are also significant differences that can affect the bioavailability of substances. These differences are in metabolism, digestive physiology, body size and composition, and species-specific factors such as genetic variations and immune responses. This is why Leap Years was specifically formulated and tested in dogs instead of simply repackaging a human supplement. Through laboratory testing, the bioavailability and optimal dosing was established in dogs prior to studying Leap Years in a double-blinded, placebo-controlled clinical trial.
By remaining vigilant, proactive, and informed about potential dog supplement drug interactions, you can help ensure the safe and effective use of medications and select the best supplements for your dog.
Summary
Anyone who has a dog knows: dogs are good for us. They help keep us healthy and feeling younger – and now we can do the same for them. Leap Years is helping to change the process of “how dogs age,” enhancing their healthspan and quality time together with the family.
Leap Years — More life in your dog, more dog in your life.
